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Mutation Information
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Mutation Site
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C109T |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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PreS2 |
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Country
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China |
Literature Information
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PubMed PMID
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23386590
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Disease
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Hepatocellular carcinoma
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Published Year
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2013 |
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Journal
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Hepatology (Baltimore, Md.) |
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Title
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Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma. |
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Author
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Xie J,Zhang Y,Zhang Q,Han Y,Yin J,Pu R,Shen Q,Lu W,Du Y,Zhao J,Han X,Zhang H,Cao G |
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Evidence
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Of those, C1653T, T1674C/G, G1719T, A1727G, T1753C, A1762T/G1764A, A1846T, G1896A, C2875A, A1C/T, C7A, C10A, A31C/T, T49A, A52C/T, C76A, G105C/T, C109A/T, A135C, G147C, preS deletion, and preS2 start codon mutation were significantly associated with an increased risk of HCC, whereas A1652G, C1673T, A1726C, A1727T, C1730G, and C1799G were significantly associated with a reduced risk of HCC, compared with the HBV‐infected subjects without HCC (after the Bonferroni correction for multiple comparison).
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HBV Mutation Detail Information