|
Mutation Information
|
Mutation Site
|
P127L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
GQ183486.1
|
|
Immune Escape
|
Y |
|
Country
|
Iran |
Literature Information
|
PubMed PMID
|
27882062
|
|
Disease
|
HBV infection
|
|
Published Year
|
2016 |
|
Journal
|
Hepatitis monthly |
|
Title
|
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran. |
|
Author
|
Ziaee M,Javanmard D,Sharifzadeh G,Hasan Namaei M,Azarkar G |
|
Evidence
|
The most amino acid substitutions of surface protein were Q129H (34.42%) and A168V (8.2%), other escape mutants observed in this study were P127L/T, S117G, T125M, S143L, D144E and E164D. In the RT gene, Q149K was the most frequently identified amino acid substitution (9.83%), followed by L122F (8.19%), N118D/T (6.55%), L157M (4.91%), and H124Y (3.27%).
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HBV Mutation Detail Information