|
Mutation Information
|
Mutation Site
|
K130M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
X |
|
Combined Mutation
|
c promoter.G1764A+c promoter.A1762T |
|
Amino acid_Mutation
|
A1762T |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
M12906
|
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
19272629
|
|
Clinical information
|
Yes
|
|
Disease
|
HBV infection
|
|
Published Year
|
2009 |
|
Journal
|
Virology |
|
Title
|
Association between genomic heterogeneity of hepatitis B virus and intrauterine infection. |
|
Author
|
Cheng H,Su H,Wang S,Shao Z,Men K,Li M,Li S,Zhang J,Xu J,Zhang H,Yan Y,Xu D |
|
Evidence
|
Because of overlapping with HBx open reading frame (ORF), the mutations of C1637G, G1658A, G1719T, G1742T, A1762T and G1764A in CP were non-synonymous in HBx ORF and resulted in the amino acid substitutions of S88C, R95K, K118R, W123L, K130M and V131I, respectively.
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HBV Mutation Detail Information