All Curated Mutation Sites in HBV

The VM annotation module provides researchers who are interested in VMs with annotations of reported pathogenic mutations in HBV related to human diseases easily. The curated mutation information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region or Disease
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S1 Promoter
|
PreS1
|
S2 Promoter
|
PreS2
|
PreS
|
S PromoterII
|
S
|
RT
|
P
|
X Promoter
|
X
|
EnhI
|
EnhII
|
BCP
|
PreC
|
C Promoter
|
C
|

ID PMID Mutation Gene/Protein/Region Description Detail
1 19272629 C3116T
PreS
G
R
CI
C
View
2 19272629 C3175T
PreS
G
R
CI
C
View
3 19272629 C96T
PreS
G
R
CI
C
View
4 19272629 T499A
PreS
G
R
CI
C
View
5 20119580 H51Q
PreS
G
R
CI
C
View
6 20595500 K24R
PreS
G
R
CI
C
View
7 20595500 Q56P
PreS
G
R
CI
C
View
8 20595500 S113T
PreS
G
R
CI
C
View
9 24379746 T2910C
PreS
G
R
CI
C
View
10 24379746 A2989C
PreS
G
R
CI
C
View
11 24379746 T3026C
PreS
G
R
CI
C
View
12 24379746 G3075A
PreS
G
R
CI
C
View
13 24379746 C3100T
PreS
G
R
CI
C
View
14 24379746 C3174T
PreS
G
R
CI
C
View
15 24379746 G35A
PreS
G
R
CI
C
View
16 24379746 T109A
PreS
G
R
CI
C
View
17 24379746 T2882C
PreS
G
R
CI
C
View
18 24379746 A2891G
PreS
G
R
CI
C
View
19 24379746 A2906G
PreS
G
R
CI
C
View
20 24379746 C2985T
PreS
G
R
CI
C
View
21 24379746 C3050T
PreS
G
R
CI
C
View
22 24379746 C3091T
PreS
G
R
CI
C
View
23 24379746 A3092C
PreS
G
R
CI
C
View
24 24379746 C3097A
PreS
G
R
CI
C
View
25 24379746 C46A
PreS
G
R
CI
C
View
26 24379746 T147C
PreS
G
R
CI
C
View
27 24379746 G97A
PreS
G
R
CI
C
View
28 24379746 C2875A
PreS
G
R
CI
C
View
29 24379746 G2927A
PreS
G
R
CI
C
View
30 24379746 A2946G
PreS
G
R
CI
C
View
31 24379746 T2958C
PreS
G
R
CI
C
View
32 24379746 G3000C
PreS
G
R
CI
C
View
33 24379746 C3008A
PreS
G
R
CI
C
View
34 24379746 C3013A
PreS
G
R
CI
C
View
35 24379746 T3031G
PreS
G
R
CI
C
View
36 24379746 C3033A
PreS
G
R
CI
C
View
37 24379746 T3051C
PreS
G
R
CI
C
View
38 24379746 A3064G
PreS
G
R
CI
C
View
39 24379746 T3066A
PreS
G
R
CI
C
View
40 24379746 A3111G
PreS
G
R
CI
C
View
41 24379746 C3116T
PreS
G
R
CI
C
View
42 24379746 G3120A
PreS
G
R
CI
C
View
43 24379746 A3186G
PreS
G
R
CI
C
View
44 24379746 G6C
PreS
G
R
CI
C
View
45 24379746 C7A
PreS
G
R
CI
C
View
46 24379746 T31C
PreS
G
R
CI
C
View
47 24379746 C52T
PreS
G
R
CI
C
View
48 24379746 T150C
PreS
G
R
CI
C
View
49 24379746 T154C
PreS
G
R
CI
C
View
50 24379746 N48H
PreS
G
R
CI
C
View
51 24379746 G27D
PreS
G
R
CI
C
View
52 24379746 Q51H
PreS
G
R
CI
C
View
53 24379746 S73G
PreS
G
R
CI
C
View
54 24379746 G16R
PreS
G
R
CI
C
View
55 24379746 S6T
PreS
G
R
CI
C
View
56 24379746 V60A
PreS
G
R
CI
C
View
57 24379746 L85F
PreS
G
R
CI
C
View
58 24379746 M12T
PreS
G
R
CI
C
View
59 24379746 N15S
PreS
G
R
CI
C
View
60 24379746 N20S
PreS
G
R
CI
C
View
61 24379746 T68I
PreS
G
R
CI
C
View
62 24379746 Q82S
PreS
G
R
CI
C
View
63 24379746 L84I
PreS
G
R
CI
C
View
64 24379746 V172A
PreS
G
R
CI
C
View
65 24379746 Q10K
PreS
G
R
CI
C
View
66 24379746 A54E
PreS
G
R
CI
C
View
67 24379746 H56N
PreS
G
R
CI
C
View
68 24379746 S62A
PreS
G
R
CI
C
View
69 24379746 A90V
PreS
G
R
CI
C
View
70 24379746 L173P
PreS
G
R
CI
C
View
71 14748061 A33L
PreS
G
S
C
View
72 14748061 G35R
PreS
G
S
C
View
73 14748061 N39S
PreS
G
S
C
View
74 14748061 N40S
PreS
G
S
C
View
75 14748061 P47K
PreS
G
S
C
View
76 14748061 P47T
PreS
G
S
C
View
77 17888035 C3026A
PreS
G
R
C
View
78 17888035 C3026T
PreS
G
R
C
View
79 18939932 T68I
PreS
G
R
C
View
80 18939932 T68V
PreS
G
R
C
View
81 19272629 A90V
PreS
G
CI
C
View
82 19272629 S3N
PreS
G
CI
C
View
83 21503942 A55T
PreS
G
R
C
View
84 21503942 E54D
PreS
G
R
C
View
85 21503942 P69L
PreS
G
R
C
View
86 21503942 G145S
PreS
G
R
C
View
87 21503942 I84L
PreS
G
R
C
View
88 21503942 L30S
PreS
G
R
C
View
89 21503942 H71Q
PreS
G
R
C
View
90 22617152 V39A
PreS
G
R
C
View
91 22617152 P41H
PreS
G
R
C
View
92 22617152 P15R
PreS
G
R
C
View
93 29434654 L30S
PreS
G
R
C
View
94 29434654 N123D
PreS
G
R
C
View
95 29434654 Q118*
PreS
G
R
C
View
96 29434654 Q118R
PreS
G
R
C
View
97 29434654 S124F
PreS
G
R
C
View
98 29434654 S124P
PreS
G
R
C
View
99 29434654 W4R
PreS
G
R
C
View
100 17888035 A60V
PreS
G
C
View
101 17888035 A60E
PreS
G
C
View
102 18216102 T53C
PreS
G
C
View
103 18216102 F141L
PreS
G
C
View
104 20337225 T3098C
PreS
G
C
View
105 20337225 T53C
PreS
G
C
View
106 20419326 C7A
PreS
S
C
View
107 20419326 G2950A
PreS
S
C
View
108 20419326 G2951A
PreS
S
C
View
109 20419326 A2962G
PreS
S
C
View
110 20419326 T3066A
PreS
S
C
View
111 20419326 T3069G
PreS
S
C
View
112 20419326 A3120T
PreS
S
C
View
113 20419326 T53C
PreS
S
C
View
114 20419326 C2875A
PreS
S
C
View
115 20419326 A3054C
PreS
S
C
View
116 20419326 A3054T
PreS
S
C
View
117 20419326 C3060A
PreS
S
C
View
118 20419326 C3060T
PreS
S
C
View
119 20419326 T3066C
PreS
S
C
View
120 20419326 G3191A
PreS
S
C
View
121 20419326 G3191C
PreS
S
C
View
122 20419326 T49A
PreS
S
C
View
123 20419326 T49G
PreS
S
C
View
124 20419326 C76A
PreS
S
C
View
125 20419326 C76T
PreS
S
C
View
126 20419326 G105C
PreS
S
C
View
127 20419326 G105T
PreS
S
C
View
128 20419326 G147C
PreS
S
C
View
129 20419326 C2875T
PreS
S
C
View
130 20419326 A2875C
PreS
S
C
View
131 20419326 C2946G
PreS
S
C
View
132 20419326 C53T
PreS
S
C
View
133 20419326 A2951G
PreS
S
C
View
134 20419326 G2962A
PreS
S
C
View
135 20419326 G3069T
PreS
S
C
View
136 20419326 T3120A
PreS
S
C
View
137 20419326 A3120C
PreS
S
C
View
138 21104161 A1C
PreS
S
C
View
139 21104161 A3054C
PreS
S
C
View
140 21104161 A3054T
PreS
S
C
View
141 21104161 A3120C
PreS
S
C
View
142 21104161 A3120T
PreS
S
C
View
143 21104161 A31C
PreS
S
C
View
144 21104161 C10A
PreS
S
C
View
145 21104161 C2875A
PreS
S
C
View
146 21104161 C2875T
PreS
S
C
View
147 21104161 C76A
PreS
S
C
View
148 21104161 C76T
PreS
S
C
View
149 21104161 C7A
PreS
S
C
View
150 21104161 G105C
PreS
S
C
View
151 21104161 G147C
PreS
S
C
View
152 21104161 G2946C
PreS
S
C
View
153 21104161 G2950A
PreS
S
C
View
154 21104161 G2951A
PreS
S
C
View
155 21104161 G3191A
PreS
S
C
View
156 21104161 G3191C
PreS
S
C
View
157 21104161 T3066A
PreS
S
C
View
158 21104161 T3066C
PreS
S
C
View
159 21104161 T3069G
PreS
S
C
View
160 21104161 C2931T
PreS
S
C
View
161 21104161 G2946A
PreS
S
C
View
162 21104161 A2962G
PreS
S
C
View
163 21104161 C2964A
PreS
S
C
View
164 21104161 C3026T
PreS
S
C
View
165 21104161 C3051T
PreS
S
C
View
166 21104161 C3063G
PreS
S
C
View
167 21104161 A3186G
PreS
S
C
View
168 21104161 A31T
PreS
S
C
View
169 21104161 T49A
PreS
S
C
View
170 21104161 A52C
PreS
S
C
View
171 21104161 A52T
PreS
S
C
View
172 21104161 T53C
PreS
S
C
View
173 21104161 G105T
PreS
S
C
View
174 21104161 C109A
PreS
S
C
View
175 21104161 C109T
PreS
S
C
View
176 21104161 A135C
PreS
S
C
View
177 21331286 T36G
PreS
G
S
View
178 21785721 3144_56 DEL126
PreS
S
C
View
179 23852705 T53C
PreS
S
C
View
180 29434654 S5A
PreS
R
C
View
181 29434654 S5P
PreS
R
C
View
182 29434654 S5T
PreS
R
C
View
183 29434654 G35R
PreS
R
C
View
184 29434654 H51P
PreS
R
C
View
185 29434654 H51R
PreS
R
C
View
186 29434654 E54K
PreS
R
C
View
187 29434654 A60V
PreS
R
C
View
188 29434654 W77R
PreS
R
C
View
189 29434654 W77*
PreS
R
C
View
190 29434654 I84T
PreS
R
C
View
191 29434654 N98K
PreS
R
C
View
192 29434654 N98T
PreS
R
C
View
193 29434654 G102R
PreS
R
C
View
194 18266648 G2858C
PreS
C
View
195 20160279 T53C
PreS
C
View
196 23404231 A79T
PreS
C
View
197 23404231 P149H
PreS
C
View
198 23404231 P160L
PreS
C
View
199 23516510 A3120G
PreS
C
View
200 23516510 A3120T
PreS
C
View
201 23516510 C2875A
PreS
C
View
202 23516510 C76A
PreS
C
View
203 23516510 C7A
PreS
C
View
204 24748463 C7A
PreS
C
View
205 24748463 C2875A
PreS
C
View
206 24748463 C76A
PreS
C
View
207 27835694 A91V
PreS
C
View
208 27835694 S101L
PreS
C
View
209 27835694 R135K
PreS
C
View
210 27835694 V90A
PreS
C
View
211 27835694 V90V
PreS
C
View
212 27835694 S96S
PreS
C
View
213 27835694 S96A
PreS
C
View
214 27835694 P173P
PreS
C
View
215 27835694 P173Q
PreS
C
View
216 27835694 A158V
PreS
C
View
217 27835694 I184I
PreS
C
View
218 27835694 I184M
PreS
C
View
219 27835694 L84I
PreS
C
View
220 27835694 A62A
PreS
C
View
221 27835694 A62T
PreS
C
View
222 27835694 L165F
PreS
C
View
223 12050364 L112F
PreS
View
224 12050364 A119L
PreS
View
225 12050364 L112I
PreS
View
226 23871771 T53C
PreS
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
Drugs mentioned in the relevant literature.
G
Genotypes/subtypes mentioned in the relevant literature.
R
Reference genomes mentioned in the relevant literature.
S
Viral sequences mentioned in the relevant literature.
C
Geographical distribution of the source mentioned in the relevant literature.
CI
Clinical information is available in the relevant literature.
I
This mutation is related to the immune escape.

Copyright © 2021.Tongji University, Life Science and Technology Department, Xiaoyan Zhang Lab.