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Mutation Information
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Mutation Site
|
C7A |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
|
PreS |
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Country
|
China |
Literature Information
|
PubMed PMID
|
23516510
|
|
Disease
|
Hepatocellular carcinoma
|
|
Published Year
|
2013 |
|
Journal
|
PloS one |
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Title
|
Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk. |
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Author
|
Han Y,Pu R,Han X,Zhao J,Zhang Y,Zhang Q,Yin J,Xie J,Shen Q,Deng Y,Ding Y,Li W,Li J,Zhang H,Cao G |
|
Evidence
|
The HBV mutations including T1674C/G, A1762T/G1764A, T1753V, C1653T, and G1896A in the EnhII/BCP/PC as well as preS deletion, preS1 start codon mutation, preS2 start codon mutation, C2875A, A3120G/T, C7A, and C76A in the preS region were significantly associated with an increased risk of HCC, while C1730G and C1799G were inversely associated with HCC risk.
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HBV Mutation Detail Information