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Mutation Information
|
Mutation Site
|
T499A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreS |
|
Nucleotide_Mutation
|
Y470N |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
M12906
|
|
Country
|
China |
Literature Information
|
PubMed PMID
|
19272629
|
|
Clinical information
|
Yes
|
|
Disease
|
HBV infection
|
|
Published Year
|
2009 |
|
Journal
|
Virology |
|
Title
|
Association between genomic heterogeneity of hepatitis B virus and intrauterine infection. |
|
Author
|
Cheng H,Su H,Wang S,Shao Z,Men K,Li M,Li S,Zhang J,Xu J,Zhang H,Yan Y,Xu D |
|
Evidence
|
Because the reverse transcriptase region of P gene overlaps with pre-S/S ORF, among these point-mutations in the pre-S/S region described above, only T473C and T499A were non-synonymous and resulted in substitutions of residues L461S and Y470N, respectively, in the reverse transcriptase domain.
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HBV Mutation Detail Information