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Mutation Information
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Mutation Site
|
K103R |
|
Mutation Type
|
|
|
Gene/Protein/Region Type
|
RT |
|
Viral Reference
|
DQ399707.1;
NC_007815.2 |
|
Relevant Drug
|
tenofovir |
Literature Information
|
PubMed PMID
|
21908397
|
|
Disease
|
XMRV infection
|
|
Published Year
|
2012 |
|
Journal
|
Nucleic acids research |
|
Title
|
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. |
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Author
|
TP Ndongwe, AO Adedeji, E Michailidis, YT Ong, A Hachiya, B Marchand, EM Ryan, DK Rai, KA Kirby, AS Whatley, DH Burke, M Johnson, S Ding, YM Zheng, SL Liu, E Kodama, KA Delviks-Frankenberry, VK Pathak, H Mitsuya, MA Parniak, K Singh, SG Sarafianos |
|
Evidence
|
We demonstrated that XMRV RT mutants K103R and Q190M, which are equivalent to HIV-1 mutants that are resistant to tenofovir (K65R) and AZT (Q151M), are also resistant to the respective drugs, suggesting that XMRV can acquire resistance to these compounds through the decreased incorporation mechanism reported in HIV-1.
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XMRV Mutation Detail Information