Literature Information
PubMed PMID
|
30531861
|
Published year
|
2018 |
Journal
|
Nature communications |
Title
|
Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress. |
Author
|
Bayard Q,Meunier L,Peneau C,Renault V,Shinde J,Nault JC,Mami I,Couchy G,Amaddeo G,Tubacher E,Bacq D,Meyer V,La Bella T,Debaillon-Vesque A,Bioulac-Sage P,Seror O,Blanc JF,Calderaro J,Deleuze JF,Imbeaud S,Zucman-Rossi J,Letouzé E |
Evidence
|
We also identified one tumor with HBV insertion and 3 tumors with AAV2 insertions in CCNA2. Finally, 6 tumors strongly overexpressed CCNA2 (FPKM > 15), 3 of which displayed 23鈥48 Mb intra-chromosomal deletions linking the intergenic region downstream CCNA2 with the highly expressed ALB, AFP, and ADH6 genes
|
|
|