XMRV VIS Detail Information

> This page shows VIS [8000008] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	18684813
Published year	2008
Journal	Journal of virology
Title	Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.
Author	Kim S,Kim N,Dong B,Boren D,Lee SA,Das Gupta J,Gaughan C,Klein EA,Lee C,Silverman RH,Chow SA
Evidence	To determine the integration site preferences of XMRV and the potential risk of proviral insertional mutagenesis, we carried out a genome-wide analysis of viral integration sites in the prostate cell line DU145 after an acute XMRV infection and compared the integration site pattern of XMRV with those found for murine leukemia virus and two human retroviruses, human immunodeficiency virus type 1 and human T-cell leukemia virus type 1. Analyses of XMRV integration sites in tissues from prostate cancer patients found a similar preference for the aforementioned chromosomal features. Additionally, XMRV integration sites in cancer tissues were associated with cancer breakpoints, common fragile sites, microRNA, and cancer-related genes, suggesting a selection process that favors certain chromosomal integration sites. In both acutely infected cells and cancer tissues, no common integration site was detected within or near proto-oncogenes or tumor suppressor genes.