MCV VIS Detail Information

> This page shows VIS [7300009] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	32833988
Published year	2020
Journal	PLoS pathogens
Title	High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms.
Author	Czech-Sioli M,Günther T,Therre M,Spohn M,Indenbirken D,Theiss J,Riethdorf S,Qi M,Alawi M,Wülbeck C,Fernandez-Cuesta I,Esmek F,Becker JC,Grundhoff A,Fischer N
Evidence	Sequence analysis suggests that linear patterns are produced during viral replication by integration of defective/linear genomes into host DNA double strand breaks via non-homologous end joining, NHEJ. In contrast, our data strongly suggest that complex integration patterns are mediated by microhomology-mediated break-induced replication, MMBIR.