Literature Information
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PubMed PMID
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30873613
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Published year
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2019 |
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Journal
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International journal of cancer |
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Title
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Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration. |
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Author
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Schrama D,Sarosi EM,Adam C,Ritter C,Kaemmerer U,Klopocki E,König EM,Utikal J,Becker JC,Houben R |
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Evidence
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The LT-truncating stop codon mutations and integration sites were affirmed in the respective clinical patient samples. Inverse PCR suggested that three of the cell lines contained MCPyV genomes as concatemers. This notion was confirmed for the two cell lines with known integration sites.
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