Literature Information
PubMed PMID
|
18202256
|
Published year
|
2008 |
Journal
|
Science (New York, N.Y.) |
Title
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Clonal integration of a polyomavirus in human Merkel cell carcinoma. |
Author
|
Feng H,Shuda M,Chang Y,Moore PS |
Evidence
|
In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells. Thus, MCV may be a contributing factor in the pathogenesis of MCC.
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