|
DVID
|
5402911 |
|
Chromosome
|
chr22 |
|
GRCh38 Location
|
41151127, 41152240 |
|
Disease
|
Cervical carcinoma |
|
Sample
|
atypical squamous cells of undetermined significance� |
|
Target Gene
|
EP300 |
Literature Information
|
PubMed PMID
|
30728408
|
|
Published year
|
2019 |
|
Journal
|
Scientific reports |
|
Title
|
Genome-wide profiling of human papillomavirus DNA integration in liquid-based cytology specimens from a Gabonese female population using HPV capture technology. |
|
Author
|
Nkili-Meyong AA,Moussavou-Boundzanga P,Labouba I,Koumakpayi IH,Jeannot E,Descorps-Declère S,Sastre-Garau X,Leroy EM,Belembaogo E,Berthet N |
|
Evidence
|
Minority genotypes (HPV33, 51, 58 and 59) were found in LSIL samples, except HPV59, which was identified in one HSIL sample. Among all the HPV genotypes identified after double capture, 10 genotypes (HPV30, 35, 39, 44, 45, 53, 56, 59, 74 and 82) were detected only in episomal form. Our study revealed that the degree of HPV integration varies with cervical cytological grade. The integration event might be a potential clinical prognostic biomarker for the prediction of the progression of neoplastic lesions.
|
|
|
HPV VIS Detail Information