HPV VIS Detail Information

> This page shows VIS [5402901] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	5402901
Chromosome	chr6
GRCh38 Location	107221398, 107226375
Disease	Cervical carcinoma
Sample	high-grade squamous intraepithelial lesions
Target Gene	PDSS2

Literature Information

PubMed PMID	30728408
Published year	2019
Journal	Scientific reports
Title	Genome-wide profiling of human papillomavirus DNA integration in liquid-based cytology specimens from a Gabonese female population using HPV capture technology.
Author	Nkili-Meyong AA,Moussavou-Boundzanga P,Labouba I,Koumakpayi IH,Jeannot E,Descorps-Declère S,Sastre-Garau X,Leroy EM,Belembaogo E,Berthet N
Evidence	Minority genotypes (HPV33, 51, 58 and 59) were found in LSIL samples, except HPV59, which was identified in one HSIL sample. Among all the HPV genotypes identified after double capture, 10 genotypes (HPV30, 35, 39, 44, 45, 53, 56, 59, 74 and 82) were detected only in episomal form. Our study revealed that the degree of HPV integration varies with cervical cytological grade. The integration event might be a potential clinical prognostic biomarker for the prediction of the progression of neoplastic lesions.