HPV VIS Detail Information

> This page shows VIS [5402541] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	5402541
Chromosome	chr1
GRCh38 Location	79629684
Disease	Cervical intraepithelial neoplasia
Sample	tumor
Target Gene	LINC01781 ADGRL4

Literature Information

PubMed PMID	31102403
Published year	2019
Journal	Carcinogenesis
Title	Risk stratification of cervical lesions using capture sequencing and machine learning method based on HPV and human integrated genomic profiles.
Author	Tian R,Cui Z,He D,Tian X,Gao Q,Ma X,Yang JR,Wu J,Das BC,Severinov K,Hitzeroth II,Debata PR,Xu W,Zhong H,Fan W,Chen Y,Jin Z,Cao C,Yu M,Xie W,Huang Z,Bao Y,Xie H,Yao S,Hu Z
Evidence	Generally, HPV integration events (11 in HPV+, 25 in CIN1 and 56 in CIN2+), non-synonymous mutations (2 in CIN1, 12 in CIN2+) and copy number variations (19.1 in HPV+, 29.4 in CIN1 and 127 in CIN2+) increased from HPV+ to CIN2+. Interestingly, 'common' deletion of mitochondrial chromosome was significantly observed in CIN2+ (P = 0.009).