Literature Information
PubMed PMID
|
31102403
|
Published year
|
2019 |
Journal
|
Carcinogenesis |
Title
|
Risk stratification of cervical lesions using capture sequencing and machine learning method based on HPV and human integrated genomic profiles. |
Author
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Tian R,Cui Z,He D,Tian X,Gao Q,Ma X,Yang JR,Wu J,Das BC,Severinov K,Hitzeroth II,Debata PR,Xu W,Zhong H,Fan W,Chen Y,Jin Z,Cao C,Yu M,Xie W,Huang Z,Bao Y,Xie H,Yao S,Hu Z |
Evidence
|
Generally, HPV integration events (11 in HPV+, 25 in CIN1 and 56 in CIN2+), non-synonymous mutations (2 in CIN1, 12 in CIN2+) and copy number variations (19.1 in HPV+, 29.4 in CIN1 and 127 in CIN2+) increased from HPV+ to CIN2+. Interestingly, 'common' deletion of mitochondrial chromosome was significantly observed in CIN2+ (P = 0.009).
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