DVID
|
5400895 |
Chromosome
|
chr4 |
GRCh38 Location
|
134901771 |
Disease
|
Cervical carcinoma |
Sample
|
tumor |
Literature Information
PubMed PMID
|
30567904
|
Published year
|
2019 |
Journal
|
Journal of medical genetics |
Title
|
Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning. |
Author
|
Huang J,Qian Z,Gong Y,Wang Y,Guan Y,Han Y,Yi X,Huang W,Ji L,Xu J,Su M,Yuan Q,Cui S,Zhang J,Bao C,Liu W,Chen X,Zhang M,Gao X,Wu R,Zhang Y,Xu H,Zhu S,Zhu H,Yang L,Xu X,Zhou P,Liang Z |
Evidence
|
In addition, HPV integration breakpoints occurred in 97.8% of the CC samples, 70.5% of the CIN samples and 42.8% of the normal cervical samples with HPV infection. Integrations of high-risk HPV strains in CCs, including HPV16, 18, 33 and 58, also occurred in the CIN samples. Moreover, gene mutations were detected in 52% of the CIN specimens, and 54.8% of these mutations occurred in genes that also mutated in CCs.
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