HPV VIS Detail Information

> This page shows VIS [5400515] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	30567904
Published year	2019
Journal	Journal of medical genetics
Title	Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning.
Author	Huang J,Qian Z,Gong Y,Wang Y,Guan Y,Han Y,Yi X,Huang W,Ji L,Xu J,Su M,Yuan Q,Cui S,Zhang J,Bao C,Liu W,Chen X,Zhang M,Gao X,Wu R,Zhang Y,Xu H,Zhu S,Zhu H,Yang L,Xu X,Zhou P,Liang Z
Evidence	In addition, HPV integration breakpoints occurred in 97.8% of the CC samples, 70.5% of the CIN samples and 42.8% of the normal cervical samples with HPV infection. Integrations of high-risk HPV strains in CCs, including HPV16, 18, 33 and 58, also occurred in the CIN samples. Moreover, gene mutations were detected in 52% of the CIN specimens, and 54.8% of these mutations occurred in genes that also mutated in CCs.