Literature Information
PubMed PMID
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32714374
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Published year
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2020 |
Journal
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Frontiers in genetics |
Title
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Accurate Detection of HPV Integration Sites in Cervical Cancer Samples Using the Nanopore MinION Sequencer Without Error Correction. |
Author
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Yang W,Liu Y,Dong R,Liu J,Lang J,Yang J,Wang W,Li J,Meng B,Tian G |
Evidence
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Among the top five most abundant breakpoints, There were 3 located in chromosome 20, HPV16:2804,chr20:32516985 (406 reads), HPV16:7139,chr20:32478733 (169 reads), HPV16:4276,chr20:32502143(51 reads), and two were in chrX, HPV16:5534,chrX:20464412 (132 reads), HPV16:3163,chrX: 20462930 (50 reads). Figure 3B indicates the integration site distribution in the HPV genome. Within the 60 identified integration sites, 18 were in the L2 gene, 12 in L1, 11 in E1, 7 in E2, and <4 in the each of the other genes (E6, LCR, E5, and E7).
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