HPV VIS Detail Information

> This page shows VIS [5004220] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 5004220
VISID TVIS20003827
Chromosome chr10
GRCh38 Location 35287563
Disease Cervical intraepithelial neoplasia  
Sample Tumor
Virus Reference Genome NC_001526.2
Target Gene CCNY     
Literature Information
PubMed PMID 27759101
Published year 2016
Journal Scientific reports
Title Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology.
Author Liu Y,Zhang C,Gao W,Wang L,Pan Y,Gao Y,Lu Z,Ke Y
Evidence HPV integration plays an important role in cervical carcinogenesis. HPV genotypes and the exact integration sites were investigated using HPV capture technology combined with next generation sequencing in 166 women. Three, one and six integration sites were verified in 7 HPV-positive 'normal cervical epithelium', 6 HPV-positive CIN2 and 15 HPV-positive CIN 3 samples, respectively. Of the 10 integrations, one and nine were involved with HPV33 and HPV16, respectively. Our study accurately evaluated HPV integration level in CINs and normal cervical tissues using high-throughput viral integration detection method providing basic evidence for HPV integration-driven cervical carcinogenesis.

Contents
Description
  • Site Information
Detail information of site [5004220]
  • Literature Information
The details of literature that this site is associated with.