HPV VIS Detail Information

> This page shows VIS [5003610] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 5003610
VISID TVIS20004702
Chromosome chr18
GRCh38 Location 63649936
Disease Cervical carcinoma  
Sample Tumor
Virus Reference Genome Not given
Target Gene SERPINB3     
Literature Information
PubMed PMID 23740984
Published year 2013
Journal Journal of virology
Title Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq.
Author Khoury JD,Tannir NM,Williams MD,Chen Y,Yao H,Zhang J,Thompson EJ,TCGA Network.,Meric-Bernstam F,Medeiros LJ,Weinstein JN,Su X
Evidence Viral integration sites were also detected in expressed transcripts using a novel approach. Integration sites of viral genes and oncogenes were detected in cancers harboring HPV or hepatitis B virus but not in EBV-positive gastric carcinoma. Integration sites of expressed viral transcripts frequently involved known coding areas of the host genome. While further validation is necessary for specific cancer types, our findings highlight the utility of RNA-Seq in detecting tumor-associated DNA viruses and identifying viral integration sites that may unravel novel mechanisms of cancer pathogenesis.

Contents
Description
  • Site Information
Detail information of site [5003610]
  • Literature Information
The details of literature that this site is associated with.