HPV VIS Detail Information

> This page shows VIS [5003601] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	5003601
VISID	TVIS20004245
Chromosome	chr2
GRCh38 Location	156324499
Disease	Head and neck squamous cell carcinoma
Sample	Tumor
Virus Reference Genome	AY686584
Target Gene	NR4A2

Literature Information

PubMed PMID	25313082
Published year	2014
Journal	Proceedings of the National Academy of Sciences of the United States of America
Title	Characterization of HPV and host genome interactions in primary head and neck cancers.
Author	Parfenov M,Pedamallu CS,Gehlenborg N,Freeman SS,Danilova L,Bristow CA,Lee S,Hadjipanayis AG,Ivanova EV,Wilkerson MD,Protopopov A,Yang L,Seth S,Song X,Tang J,Ren X,Zhang J,Pantazi A,Santoso N,Xu AW,Mahadeshwar H,Wheeler DA,Haddad RI,Jung J,Ojesina AI,Issaeva N,Yarbrough WG,Hayes DN,Grandis JR,El-Naggar AK,Meyerson M,Park PJ,Chin L,Seidman JG,Hammerman PS,Kucherlapati R,Cancer Genome Atlas Network.
Evidence	Twenty-five cases had integration of the viral genome into one or more locations in the human genome with statistical enrichment for genic regions. Integrations had a marked impact on the human genome and were associated with alterations in DNA copy number, mRNA transcript abundance and splicing, and both inter- and intrachromosomal rearrangements. Cancers with integrated vs. nonintegrated HPV displayed different patterns of DNA methylation and both human and viral gene expressions. Together, these data provide insight into the mechanisms by which HPV interacts with the human genome beyond expression of viral oncoproteins and suggest that specific integration events are an integral component of viral oncogenesis.