HPV VIS Detail Information

> This page shows VIS [5003227] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	30679491
Published year	2019
Journal	Scientific reports
Title	TaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration.
Author	Lagström S,Umu SU,Lepistö M,Ellonen P,Meisal R,Christiansen IK,Ambur OH,Rounge TB
Evidence	HPV genomic variability and chromosomal integration are important in the HPV-induced carcinogenic process. TaME-seq combines tagmentation and multiplex PCR enrichment for simultaneous analysis of HPV variation and chromosomal integration, and it can also be adapted to other viruses. Chromosomal integration breakpoints and large deletions were identified in HPV positive cell lines and in one clinical sample. Efficient identification of both HPV variability and integration sites will be important for the study of HPV evolution and adaptability and may be an important tool for use in cervical cancer diagnostics.