HPV VIS Detail Information

> This page shows VIS [5001994] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	5001994
VISID	TVIS20003825
Chromosome	chr11
GRCh38 Location	68506617
Disease	Cervical intraepithelial neoplasia
Sample	Tumor
Virus Reference Genome	NC_001526.2
Target Gene	PPP6R3

Literature Information

PubMed PMID	27759101
Published year	2016
Journal	Scientific reports
Title	Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology.
Author	Liu Y,Zhang C,Gao W,Wang L,Pan Y,Gao Y,Lu Z,Ke Y
Evidence	HPV integration plays an important role in cervical carcinogenesis. HPV genotypes and the exact integration sites were investigated using HPV capture technology combined with next generation sequencing in 166 women. Three, one and six integration sites were verified in 7 HPV-positive 'normal cervical epithelium', 6 HPV-positive CIN2 and 15 HPV-positive CIN 3 samples, respectively. Of the 10 integrations, one and nine were involved with HPV33 and HPV16, respectively. Our study accurately evaluated HPV integration level in CINs and normal cervical tissues using high-throughput viral integration detection method providing basic evidence for HPV integration-driven cervical carcinogenesis.