HPV VIS Detail Information

> This page shows VIS [5000978] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	23740984
Published year	2013
Journal	Journal of virology
Title	Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq.
Author	Khoury JD,Tannir NM,Williams MD,Chen Y,Yao H,Zhang J,Thompson EJ,TCGA Network.,Meric-Bernstam F,Medeiros LJ,Weinstein JN,Su X
Evidence	Viral integration sites were also detected in expressed transcripts using a novel approach. Integration sites of viral genes and oncogenes were detected in cancers harboring HPV or hepatitis B virus but not in EBV-positive gastric carcinoma. Integration sites of expressed viral transcripts frequently involved known coding areas of the host genome. While further validation is necessary for specific cancer types, our findings highlight the utility of RNA-Seq in detecting tumor-associated DNA viruses and identifying viral integration sites that may unravel novel mechanisms of cancer pathogenesis.