HPV VIS Detail Information

> This page shows VIS [5000497] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 5000497
VISID TVIS20004229
Chromosome chr14
GRCh38 Location 68274983
Disease Head and neck squamous cell carcinoma  
Sample Tumor
Virus Reference Genome AY686584
Target Gene RAD51B     
Literature Information
PubMed PMID 25313082
Published year 2014
Journal Proceedings of the National Academy of Sciences of the United States of America
Title Characterization of HPV and host genome interactions in primary head and neck cancers.
Author Parfenov M,Pedamallu CS,Gehlenborg N,Freeman SS,Danilova L,Bristow CA,Lee S,Hadjipanayis AG,Ivanova EV,Wilkerson MD,Protopopov A,Yang L,Seth S,Song X,Tang J,Ren X,Zhang J,Pantazi A,Santoso N,Xu AW,Mahadeshwar H,Wheeler DA,Haddad RI,Jung J,Ojesina AI,Issaeva N,Yarbrough WG,Hayes DN,Grandis JR,El-Naggar AK,Meyerson M,Park PJ,Chin L,Seidman JG,Hammerman PS,Kucherlapati R,Cancer Genome Atlas Network.
Evidence Twenty-five cases had integration of the viral genome into one or more locations in the human genome with statistical enrichment for genic regions. Integrations had a marked impact on the human genome and were associated with alterations in DNA copy number, mRNA transcript abundance and splicing, and both inter- and intrachromosomal rearrangements. Cancers with integrated vs. nonintegrated HPV displayed different patterns of DNA methylation and both human and viral gene expressions. Together, these data provide insight into the mechanisms by which HPV interacts with the human genome beyond expression of viral oncoproteins and suggest that specific integration events are an integral component of viral oncogenesis.

Contents
Description
  • Site Information
Detail information of site [5000497]
  • Literature Information
The details of literature that this site is associated with.