HPV VIS Detail Information

> This page shows VIS [5000459] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	24418928
Published year	2014
Journal	International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Title	Simultaneous characterization of somatic events and HPV-18 integration in a metastatic cervical carcinoma patient using DNA and RNA sequencing.
Author	Liang WS,Aldrich J,Nasser S,Kurdoglu A,Phillips L,Reiman R,McDonald J,Izatt T,Christoforides A,Baker A,Craig C,Egan JB,Chase DM,Farley JH,Bryce AH,Stewart AK,Borad MJ,Carpten JD,Craig DW,Monk BJ
Evidence	OBJECTIVE: Integration of carcinogenic human papillomaviruses (HPVs) into the host genome is a significant tumorigenic factor in specific cancers including cervical carcinoma. Although major strides have been made with respect to HPV diagnosis and prevention, identification and development of efficacious treatments for cervical cancer patients remains a goal and thus requires additional detailed characterization of both somatic events and HPV integration. Sequencing also revealed the HPV type 18 (HPV-18) integration in the metastasis. Using both DNA and RNA reads, we pinpointed 3 major events indicating HPV-18 integration into an intronic region of chromosome 6p25. This integration site has not been reported for HPV-18. CONCLUSIONS: We demonstrate that DNA and RNA sequencing can be used to concurrently characterize somatic alterations and expression changes in a biopsy and delineate HPV integration at base resolution in cervical cancer.