HPV VIS Detail Information

> This page shows VIS [5000254] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 5000254
VISID TVIS20004423
Chromosome chr1
GRCh38 Location 629398
Disease Oropharyngeal squamous cell carcinoma  
Sample Tumor
Virus Reference Genome NC_001526.1
Target Gene MTND2P28     
Literature Information
PubMed PMID 24586376
Published year 2014
Journal PloS one
Title Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.
Author Olthof NC,Speel EJ,Kolligs J,Haesevoets A,Henfling M,Ramaekers FC,Preuss SF,Drebber U,Wieland U,Silling S,Lam WL,Vucic EA,Kremer B,Klussmann JP,Huebbers CU
Evidence However, it is unclear whether viral integration is an essential hallmark in the carcinogenic process of OSCC and whether HPV integration correlates with the level of viral gene transcription and influences the expression of disrupted host genes. Viral integration was examined using DIPS- as well as APOT-PCR. We identified 37 HPV16-human fusion products indicating viral integration in 29 (39%) OSCC. When comparing OSCC with or without an integration-derived fusion product, we did not find significant differences in the mean RNA expression of viral genes E2, E6 and E7 or the viral copy numbers per cell, nor did the RNA expression of the HPV-disrupted genes differ from either group of OSCC. In conclusion, our data do not support the hypothesis that integration affects the levels of viral and/or HPV-disrupted human gene transcripts.

Contents
Description
  • Site Information
Detail information of site [5000254]
  • Literature Information
The details of literature that this site is associated with.