HIV VIS Detail Information

> This page shows VIS [4016740] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 4016740
VISID TVIS30014622
Chromosome chr1
GRCh38 Location 198537586, 198537659
Disease HIV infection/AIDS  
Sample PBMC
Virus Reference Genome Not given
Target Gene ATP6V1G3     
Literature Information
PubMed PMID 24968937
Published year 2014
Journal Science (New York, N.Y.)
Title HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.
Author Maldarelli F,Wu X,Su L,Simonetti FR,Shao W,Hill S,Spindler J,Ferris AL,Mellors JW,Kearney MF,Coffin JM,Hughes SH
Evidence HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.

Contents
Description
  • Site Information
Detail information of site [4016740]
  • Literature Information
The details of literature that this site is associated with.