HIV VIS Detail Information

> This page shows VIS [4014807] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 4014807
VISID TVIS30013899
Chromosome chr6
GRCh38 Location 90035789
Disease AIDS-associated lymphoma  
Sample Tumor
Virus Reference Genome Not given
Target Gene BACH2     
Literature Information
PubMed PMID 12843741
Published year 2003
Journal Journal of acquired immune deficiency syndromes (1999)
Title HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression.
Author Mack KD,Jin X,Yu S,Wei R,Kapp L,Green C,Herndier B,Abbey NW,Elbaggari A,Liu Y,McGrath MS
Evidence HIV integration within host cell genomic DNA is a requisite step of the viral infection cycle. Yet, characteristics of the sites of provirus integration within the host genome remain obscure. The authors present evidence that in diseased tissues showing a high level of HIV DNA and macrophage-associated HIV p24 antigen expression from end stage forms of HIV disease, HIV-1 integration sites were favored within genes and transcriptionally active host cell genomic loci. Using an inverse PCR (IPCR) technique that identified dominant integrated forms of HIV, clonal IPCR products were isolated from AIDS dementia, AIDS lymphoma, and angioimmunoblastic lymphadenopathy tissues. HIV-1 integration within host cell genomic DNA potentially represents a significant insertional mutagenic event.

Contents
Description
  • Site Information
Detail information of site [4014807]
  • Literature Information
The details of literature that this site is associated with.