HIV VIS Detail Information

> This page shows VIS [4010083] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	12843741
Published year	2003
Journal	Journal of acquired immune deficiency syndromes (1999)
Title	HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression.
Author	Mack KD,Jin X,Yu S,Wei R,Kapp L,Green C,Herndier B,Abbey NW,Elbaggari A,Liu Y,McGrath MS
Evidence	HIV integration within host cell genomic DNA is a requisite step of the viral infection cycle. Yet, characteristics of the sites of provirus integration within the host genome remain obscure. The authors present evidence that in diseased tissues showing a high level of HIV DNA and macrophage-associated HIV p24 antigen expression from end stage forms of HIV disease, HIV-1 integration sites were favored within genes and transcriptionally active host cell genomic loci. Using an inverse PCR (IPCR) technique that identified dominant integrated forms of HIV, clonal IPCR products were isolated from AIDS dementia, AIDS lymphoma, and angioimmunoblastic lymphadenopathy tissues. HIV-1 integration within host cell genomic DNA potentially represents a significant insertional mutagenic event.