DVID
|
4006620 |
VISID
|
TVIS30000977
|
Chromosome
|
chr16 |
GRCh38 Location
|
68046751, 68047044 |
Disease
|
HIV infection/AIDS |
Sample
|
PBMC |
Virus Reference Genome
|
Not given |
Target Gene
|
DUS2 |
Literature Information
PubMed PMID
|
25011556
|
Published year
|
2014 |
Journal
|
Science (New York, N.Y.) |
Title
|
HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. |
Author
|
Wagner TA,McLaughlin S,Garg K,Cheung CY,Larsen BB,Styrchak S,Huang HC,Edlefsen PT,Mullins JI,Frenkel LM |
Evidence
|
We evaluated the contribution of infected-cell proliferation and sites of proviral integration to HIV persistence. A total of 534 HIV integration sites (IS) and 63 adjacent HIV env sequences were derived from three study participants over 11. Each participant had identical viral sequences integrated at the same position in multiple cells, demonstrating infected-cell proliferation. Integrations were overrepresented in genes associated with cancer and favored in 12 genes across multiple participants. HIV integration into specific genes may promote proliferation of HIV-infected cells, slowing viral decay during ART.
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