HIV VIS Detail Information

> This page shows VIS [4005192] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	23953889
Published year	2013
Journal	Retrovirology
Title	HIV latency and integration site placement in five cell-based models.
Author	Sherrill-Mix S,Lewinski MK,Famiglietti M,Bosque A,Malani N,Ocwieja KE,Berry CC,Looney D,Shan L,Agosto LM,Pace MJ,Siliciano RF,O'Doherty U,Guatelli J,Planelles V,Bushman FD
Evidence	BACKGROUND: HIV infection can be treated effectively with antiretroviral agents, but the persistence of a latent reservoir of integrated proviruses prevents eradication of HIV from infected individuals. The chromosomal environment of integrated proviruses has been proposed to influence HIV latency, but the determinants of transcriptional repression have not been fully clarified, and it is unclear whether the same molecular mechanisms drive latency in different cell culture models. Cells were infected in vitro and separated into fractions containing proviruses that were either expressed or silent/inducible, and integration site populations sequenced from each.