HIV VIS Detail Information

> This page shows VIS [4003516] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 4003516
VISID TVIS30014300
Chromosome chr2
GRCh38 Location 224904259
Disease HIV infection/AIDS  
Sample PBMC
Virus Reference Genome Not given
Target Gene DOCK10     
Literature Information
PubMed PMID 17262715
Published year 2007
Journal The Journal of infectious diseases
Title Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy.
Author Ikeda T,Shibata J,Yoshimura K,Koito A,Matsushita S
Evidence To determine the contribution of integration sites to viral latency within clinical settings, an inverse polymerase chain reaction method was used to analyze integration sites in CD4(+) T cells from patients showing long-term undetectable plasma viral RNA. Studies of 18 genes in which HIV-1 integrates found them to be actively expressed in resting CD4(+) T cells. On the other hand, integration sites in the alpha satellite region was also identified in some patients, albeit at low frequency. Of particular interest, HIV-1-infected cells with multiple identical integration sites were detected in longitudinal analysis of samples from 3 patients, suggesting that these cells persist for long periods and that clonal expansion may occur. Furthermore, strong integration clusters in the BACH2 gene were observed in 2 patients (31% in patient 1 and 5% in patient 3). Our findings not only raise the possibility of biased target-site integration but also provide mechanistic insights into the long-term persistence of HIV-1.

Contents
Description
  • Site Information
Detail information of site [4003516]
  • Literature Information
The details of literature that this site is associated with.