HIV VIS Detail Information

> This page shows VIS [4000387] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	25011556
Published year	2014
Journal	Science (New York, N.Y.)
Title	HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection.
Author	Wagner TA,McLaughlin S,Garg K,Cheung CY,Larsen BB,Styrchak S,Huang HC,Edlefsen PT,Mullins JI,Frenkel LM
Evidence	We evaluated the contribution of infected-cell proliferation and sites of proviral integration to HIV persistence. A total of 534 HIV integration sites (IS) and 63 adjacent HIV env sequences were derived from three study participants over 11. Each participant had identical viral sequences integrated at the same position in multiple cells, demonstrating infected-cell proliferation. Integrations were overrepresented in genes associated with cancer and favored in 12 genes across multiple participants. HIV integration into specific genes may promote proliferation of HIV-infected cells, slowing viral decay during ART.