Literature Information
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PubMed PMID
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14982850
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Published year
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2004 |
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Journal
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The American journal of pathology |
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Title
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Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression. |
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Author
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Takakuwa T,Luo WJ,Ham MF,Sakane-Ishikawa F,Wada N,Aozasa K |
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Evidence
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The BamHI-W fragment and the adjacent part of chromosome 6 showed 70% homology, while no homology was found between the BamHI-D and adjacent host sequences. EBV was present at intron 1 of the BACH2 gene located on chromosome 6q15. BACH2 was not expressed in the Raji cell line. Because BACH2 is a putative tumor suppressor gene, loss of its expression through EBV integration might contribute to lymphomagenesis.
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EBV VIS Detail Information