EBV VIS Detail Information

> This page shows VIS [3000471] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	15241441
Published year	2004
Journal	Laboratory investigation; a journal of technical methods and pathology
Title	Epstein-Barr virus is integrated between REL and BCL-11A in American Burkitt lymphoma cell line (NAB-2).
Author	Luo WJ,Takakuwa T,Ham MF,Wada N,Liu A,Fujita S,Sakane-Ishikawa E,Aozasa K
Evidence	The NAB-2 line, which was established from a North American Burkitt's tumor, was indicated to contain one copy of EBV DNA as the integrated form into chromosome 2p13 of the host genome. To demonstrate the integration site of EBV directly, and to clarify the relation between the integration sites and the oncogenes, fragments containing the nucleotide sequence of NAB-2 integration sites were cloned. EBV was integrated via the terminal repeats (TR), and integration sites located in the clone RP11-440P5 on chromosome 2, between two oncogenes, REL and BCL11A, which is apart from approximately 350 kbp from each other. The integration site 2p13 overlaps with common fragile site, FRA2E. Integration event in NAB-2 might alter the regulation of the oncogenes and provide advantage for continuous cell proliferation.