AAV2 VIS Detail Information

> This page shows VIS [2100003] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	31375600
Published year	2020
Journal	Gut
Title	Adeno-associated virus in the liver: natural history and consequences in tumour development.
Author	T La Bella, S Imbeaud, C Peneau, I Mami, S Datta, Q Bayard, S Caruso, TZ Hirsch, J Calderaro, G Morcrette, C Guettier, V Paradis, G Amaddeo, A Laurent, L Possenti, L Chiche, P Bioulac-Sage, JF Blanc, E Letouze, JC Nault, J Zucman-Rossi
Evidence	We provided an integrated analysis of the wild-type AAV infection in the liver with the identification of viral genotypes, molecular forms, helper virus relationship and viral integrations. Clonal AAV insertions were positive selected during HCC development on non-cirrhotic liver challenging the notion of AAV as a non-pathogenic virus.