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AAV2 VIS Detail Information

> This page shows VIS [2000010] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 2000010
VISID TVIS10000440
Chromosome chr3
GRCh38 Location 172506236
Disease Hepatocellular carcinoma  
Sample Tumor
Virus Reference Genome AF043303.1
Target Gene TNFSF10     
Literature Information
PubMed PMID 26301494
Published year 2015 Oct
Journal Nature genetics
Title Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
Author Nault JC, Datta S, Imbeaud S, Franconi A, Mallet M, Couchy G,et.al
Evidence We found clonal integration of adeno-associated virus type 2 (AAV2) in 11 of 193 HCCs. These AAV2 integrations occurred in known cancer driver genes, namely CCNA2 (cyclin A2; four cases), TERT (telomerase reverse transcriptase; one case), CCNE1 (cyclin E1; three cases), TNFSF10 (tumor necrosis factor superfamily member 10; two cases) and KMT2B (lysine-specific methyltransferase 2B; one case), leading to overexpression of the target genes. Tumors with viral integration mainly developed in non-cirrhotic liver (9 of 11 cases) and without known risk factors (6 of 11 cases), suggesting a pathogenic role for AAV2 in these patients.
Contents
Description
  • Site Information
Detail information of site [2000010]
  • Literature Information
The details of literature that this site is associated with.