HBV VIS Detail Information

> This page shows VIS [1404626] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	1404626
Chromosome	chr5
GRCh38 Location	4147421
Disease	Hepatocellular carcinoma
Sample	tumor and paired cfDNA samples

Literature Information

PubMed PMID	32100258
Published year	2020
Journal	Hepatology international
Title	Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.
Author	Chen W,Zhang K,Dong P,Fanning G,Tao C,Zhang H,Guo S,Wang Z,Hong Y,Yang X,Lai S,Ding H,Zhao H,Zeng C,Protzer U,Zhang D
Evidence	We achieve the efficient enrichment of plasma cell-free chimeric DNA from integration site, and demonstrate that chimeric DNA profiling in plasma is a promising noninvasive approach to monitor HBV integration in liver cancer development and to determine the ability of integrated sequences to express viral proteins that can be targeted, e.g. by immunotherapies.