Literature Information
PubMed PMID
|
30704462
|
Published year
|
2019 |
Journal
|
BMC medical genomics |
Title
|
Detecting virus integration sites based on multiple related sequencing data by VirTect. |
Author
|
Xia Y,Liu Y,Deng M,Xi R |
Evidence
|
We develop VirTect for detecting virus integration sites simultaneously from multiple related-sample data. This algorithm is mainly based on the joint analysis of short reads spanning breakpoints of integration sites from multiple samples. To achieve high specificity and breakpoint accuracy, a local precise sandwich alignment algorithm is used. Simulation and real data analyses show that, compared with other algorithms, VirTect is significantly more sensitive and has a similar or lower false discovery rate.
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