Literature Information
PubMed PMID
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32592629
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Published year
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2020 |
Journal
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Journal of viral hepatitis |
Title
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Deep sequencing of liver explant transcriptomes reveals extensive expression from integrated hepatitis B virus DNA. |
Author
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Ringlander J,Skoglund C,Prakash K,Andersson ME,Larsson SB,Tang KW,Rydell GE,Abrahamsson S,Castedal M,Norder H,Hellstrand K,Lindh M |
Evidence
|
Hence, HBV transcripts from integrated HBV DNA rather than from covalently closed circular HBV DNA (cccDNA) predominated in late-stage HBV infection, in particular in cases with hepatitis D virus co-infection. The findings support the suggestion that integrated HBV DNA can be a significant source of HBsAg in humans.
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