Literature Information
PubMed PMID
|
25627239
|
Published year
|
2015 |
Journal
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Hepatology (Baltimore, Md.) |
Title
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Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. |
Author
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Yan H,Yang Y,Zhang L,Tang G,Wang Y,Xue G,Zhou W,Sun S |
Evidence
|
Here, we report a comparative study of HBV subgenotypes and integration in early- (=30) and late-onset (>/=70) HBV-associated HCC using a novel high-throughput viral integration detection method. HBV integration is a common phenomenon, both in early- and late-onset HCC, which favors integrating into human repeat regions. HBV integrating this site results in c-MYC, PVT1, and microRNA-1204 overexpression in tumors, thereby potentially contributing to the development of early-onset HCC. CONCLUSION: HBV genotype and integration patterns may be distinct in early-onset HCC. Further studies are needed to elucidate at which time in tumor development this integration event occurs and whether it plays an important, causative role in HCC development or progression.
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