HBV VIS Detail Information

> This page shows VIS [1013521] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	23867110
Published year	2013
Journal	Genomics
Title	HIVID: an efficient method to detect HBV integration using low coverage sequencing.
Author	Li W,Zeng X,Lee NP,Liu X,Chen S,Guo B,Yi S,Zhuang X,Chen F,Wang G,Poon RT,Fan ST,Mao M,Li Y,Li S,Wang J,Jianwang,Xu X,Jiang H,Zhang X
Evidence	We reported HIVID (high-throughput Viral Integration Detection), a novel experimental and computational method to detect the location of Hepatitis B Virus (HBV) integration breakpoints in Hepatocellular Carcinoma (HCC) genome. We detected a total of 246 HBV integration breakpoints in HCC genome, 113 out of which were within 400bp upstream or downstream of 125 breakpoints identified by WGS method, covering 89. The integration was located in the gene TERT, MLL4, and CCNE1. Our study shows HIVID is a cost-effective methodology with high specificity and sensitivity to identify viral integration in human genome.