HBV VIS Detail Information

> This page shows VIS [1013045] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	1013045
VISID	TVIS10006521
Chromosome	chr5
GRCh38 Location	65472122
Disease	Hepatocellular carcinoma
Sample	Tumor
Virus Reference Genome	V01460.1
Target Gene	ADAMTS6

Literature Information

PubMed PMID	27453547
Published year	2016
Journal	Gastroenterology
Title	HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant.
Author	Mason WS,Gill US,Litwin S,Zhou Y,Peri S,Pop O,Hong ML,Naik S,Quaglia A,Bertoletti A,Kennedy PT
Evidence	We examined HBV-DNA integration, clonal hepatocyte expansion, HBV antigen expression, and HBV-specific immune responses in patients in the immune-tolerant phase to assess whether this designation is appropriate or if there is evidence of disease activity. METHODS: We studied HBV-DNA integration, clonal hepatocyte expansion, and expression of hepatitis B surface antigen and core antigen in liver tissues from 26 patients with chronic HBV infection (ages, 14-39 y); 9 patients were positive for hepatitis B e antigen (HBeAg) in the immune-tolerant phase and were matched for age with 10 HBeAg-positive patients with active disease and 7 HBeAg-negative patients with active disease. However, unexpectedly high numbers of HBV-DNA integrations, randomly distributed among chromosomes, were detected in all groups. CONCLUSIONS: We measured HBV-specific T cells, HBV-DNA integration, and clonal hepatocyte expansion in different disease phases of young patients with chronic hepatitis B, with emphasis on the so-called immune-tolerant phase. A high level of HBV-DNA integration and clonal hepatocyte expansion in patients considered immune tolerant indicated that hepatocarcinogenesis could be underway-even in patients with early stage chronic HBV infection.