HBV VIS Detail Information

> This page shows VIS [1011250] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 1011250
VISID TVIS10020014
Chromosome chr12
GRCh38 Location 2915082
Disease Hepatocellular carcinoma  
Sample Unknown
Virus Reference Genome Not given
Literature Information
PubMed PMID 12813464
Published year 2003
Journal Oncogene
Title Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.
Author Paterlini-Bréchot P,Saigo K,Murakami Y,Chami M,Gozuacik D,Mugnier C,Lagorce D,Bréchot C
Evidence Integration of Hepatitis B Virus (HBV) DNA into liver cell DNA has been well established, but its implication in liver carcinogenesis is still being debated. By using HBV-Alu PCR, we have now isolated, from nine hepatocellular carcinomas, nine HBV-DNA integration sites showing that the viral genome mutates key regulatory cellular genes: neurotropic tyrosin receptor kinase 2 (NTRK2) gene, IL-1R-associated kinase 2 (IRAK2) gene, p42 mitogen-activated protein kinase 1 (p42MAPK1) gene, inositol 1,4,5-triphosphate receptor type 2 (IP3R2) gene, inositol 1,4,5-triphosphate receptor (IP3R) type 1 (IP3R1) gene, alpha 2,3 sialyltransferase (ST3GAL VI or SITA) gene, thyroid hormone uncoupling protein (TRUP) gene, EMX2-like gene, and human telomerase reverse transcriptase (hTERT) gene. Thus, HBV frequently targets cellular genes involved in cell signalling and some of them may be preferential targets of the viral integration.

Contents
Description
  • Site Information
Detail information of site [1011250]
  • Literature Information
The details of literature that this site is associated with.