HBV VIS Detail Information

> This page shows VIS [1010263] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	26867494
Published year	2016
Journal	Journal of hepatology
Title	Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma.
Author	Chiu YT,Wong JK,Choi SW,Sze KM,Ho DW,Chan LK,Lee JM,Man K,Cherny S,Yang WL,Wong CM,Sham PC,Ng IO
Evidence	BACKGROUND & AIMS: Hepatitis B virus (HBV) integration is common in HBV-associated hepatocellular carcinoma (HCC) and may play an important pathogenic role through the production of chimeric HBV-human transcripts. We aimed to screen the transcriptome for HBV integrations in HCCs. Upon the integration of HBV into the intron of the CCNA2 gene, the mammalian splicing machinery utilized the foreign splice sites at 282nt. This represents a novel and possibly common mechanism underlying the formation of HBV-human chimeric transcripts from intronically integrated HBV genome with functional impact. This study also provided insight on the impact of intronic HBV integration with the gain of splice sites in the development of HBV-associated HCC.