HBV VIS Detail Information

> This page shows VIS [1010232] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	22962577
Published year	2012
Journal	PloS one
Title	Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis.
Author	Jiang S,Yang Z,Li W,Li X,Wang Y,Zhang J,Xu C,Chen PJ,Hou J,McCrae MA,Chen X,Zhuang H,Lu F
Evidence	To examine the role of hepatitis B virus (HBV) integration in hepatocarcinogenesis, a systematic comparative study of both tumor and their corresponding non-tumor derived tissue has been conducted in a cohort of 60 HBV associated hepatocellular carcinoma (HCC) patients. No direct correlation between chromosome aberrations and the number of HBV integration events was found using a sensitive array-based comparative genomic hybridization (aCGH) assay. Strikingly, approximately 24% of the integrations examined had a breakpoint in a short 15 nt viral genome region (1820-1834 nt). Furthermore, the integrated viral sequences in both groups had a similar low frequency of C1653T, T1753V and A1762T/G1764A mutations. The frequency and patterns of HBV insertions were similar between tumor and their adjacent non-tumor samples indicating that the majority of HBV DNA integration events are not associated with hepatocarcinogenesis.