|
DVID
|
1009035 |
|
VISID
|
TVIS10015597
|
|
Chromosome
|
chr1 |
|
GRCh38 Location
|
67504010 |
|
Disease
|
Hepatocellular carcinoma |
|
Sample
|
Adjacent tissue |
|
Virus Reference Genome
|
AY800389.1;AY800390.1;AY800391.1;AY800392.1 |
Literature Information
|
PubMed PMID
|
23236287
|
|
Published year
|
2012 |
|
Journal
|
PLoS genetics |
|
Title
|
Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach. |
|
Author
|
Ding D,Lou X,Hua D,Yu W,Li L,Wang J,Gao F,Zhao N,Ren G,Li L,Lin B |
|
Evidence
|
Integration of the viral DNA into host chromosomes was found in most of the hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs). Applying MAPS to 40 pairs of HBV-related HCC tissues (cancer and adjacent tissues), we identified 296 HBV integration events corresponding to 286 unique integration sites (UISs) with precise HBV-Human DNA junctions. HBV integration favored chromosome 17 and preferentially integrated into human transcript units. Fewer integration events were found in cancers compared to cancer-adjacent tissues, suggesting a clonal expansion model in HCC development. Finally, we identified 8 genes that were recurrent target genes by HBV integration including fibronectin 1 (FN1) and telomerase reverse transcriptase (TERT1), two known recurrent target genes, and additional novel target genes such as SMAD family member 5 (SMAD5), phosphatase and actin regulator 4 (PHACTR4), and RNA binding protein fox-1 homolog (C. Integrating analysis with recently published whole-genome sequencing analysis, we identified 14 additional recurrent HBV target genes, greatly expanding the HBV recurrent target list. This global survey of HBV integration events, together with recently published whole-genome sequencing analyses, furthered our understanding of the HBV-related HCC.
|
|
|
HBV VIS Detail Information