HBV VIS Detail Information

> This page shows VIS [1007851] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	22267523
Published year	2012
Journal	Genome research
Title	The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.
Author	Jiang Z,Jhunjhunwala S,Liu J,Haverty PM,Kennemer MI,Guan Y,Lee W,Carnevali P,Stinson J,Johnson S,Diao J,Yeung S,Jubb A,Ye W,Wu TD,Kapadia SB,de Sauvage FJ,Gentleman RC,Stern HM,Seshagiri S,Pant KP,Modrusan Z,Ballinger DG,Zhang Z
Evidence	HBV integration into the host genome has been reported, but its scale, impact and contribution to HCC development is not clear. Here, we sequenced the tumor and nontumor genomes (>80x coverage) and transcriptomes of four HCC patients and identified 255 HBV integration sites. Increased sequencing to 240x coverage revealed a proportionally higher number of integration sites. Clonal expansion of HBV-integrated hepatocytes was found specifically in tumor samples. We observe a diverse collection of genomic perturbations near viral integration sites, including direct gene disruption, viral promoter-driven human transcription, viral-human transcript fusion, and DNA copy number alteration. Thus, we report the most comprehensive characterization of HBV integration in hepatocellular carcinoma patients. Such widespread random viral integration will likely increase carcinogenic opportunities in HBV-infected individuals.